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Battle of the COVID-19 treatments under investigation around the world

Battle of the COVID-19 treatments under investigation around the world Remdesivir: New antiviral also referred to as GS-5734 (injection given IV)  It was initially developed to treat the Ebola virus…

Battle of the COVID-19 treatments under investigation around the world

  1. Remdesivir:
  2. Favipiravir :
    • Only commercialized and available in Japan and China for the treatment of influenza (3)
    • Oral drug (more practical for outpatients)
    • Because of some positive data related to COVID-19 from anecdotal Chinese experiments, a clinical trial on Favipiravir is set to start soon in the US. The only active clinical trial that have started so far is in Italy
    • The goal is to evaluate the performance and safety of Favipiravir for adult patients with moderate COVID-19 symptoms.
  3. Lopinavir/ritonavir (Kaletra):
  4. Interleukin-6 inhibitor (Tocilizumab)
    • Injection medication that we use in autoimmune conditions such as rheumatoid arthritis
    • To understand how this medication works for COVID-19, click on my Youtube video above at 7:05
    • Small case series in Wuhan, China
    • In the Chinese treatment guidelines for COVID-19. It is reserved for severe cases of COVID-19 with high levels of IL-6.
    • There are currently some randomized clinical trials that are recruiting participants around the world, particularly in Italy, Spain and US
      • Goal: evaluate the safety and efficacy of tocilizumab and others IL-6 inhibitors (sarilumab and siltuximab) in severe COVID-19.
  5. Colchicine
    • Already in the market and is primarily used to treat inflammatory conditions such as gout
      • (Gout is a form of inflammatory arthritis that usually affects a single joint like the big toe)
    • Also targets that inflammatory storm caused by the release of cytokines (similar to IL-6 inhibitors)
    • Oral drug, inexpensive and less severe side effects
    • In the COVID-19 context, it’s been hypothesized that reducing the inflammatory and immune reaction with colchicine will prevent the complications of COVID-19 infections such as ARDS.
    • COLCORONA trial:
  6. Vaccines
    • There are many that are being evaluated for prevention of COVID-19
    • Some interest is on a vaccine that already exists. It’s called Bacillus Calmette-Guérin (BCG). 
    • Phase 3 clinical trial that is planned in Netherlands:
    • Convalescent plasma:
        • To have more information about this treatment, click on Youtube video above at 12:43 (6)

Here is the link to lean more about the most clinical trials about hydroxychloroquine and chloroquine, watch this Youtube article: https://www.youtube.com/watch?v=yJW-J9nyyGs

Other references:

  1. https://www.ncbi.nlm.nih.gov/pubmed?term=31774950
  2. https://www.ncbi.nlm.nih.gov/pubmed?term=32020029
  3. https://ascpt.onlinelibrary.wiley.com/doi/epdf/10.1002/cpt.1844
  4. https://www.ncbi.nlm.nih.gov/pubmed?term=15766649
  5. https://www.ncbi.nlm.nih.gov/pubmed?term=26198719
  6. https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/recommendations-investigational-covid-19-convalescent-plasma

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